Environmental Risk Factors for Colorectal Cancer

The Lead Investigator: William E Funk, PhD, Associate Professor, Preventive Medicine (Epidemiology)

The Issue:

Colorectal cancer is the third leading cause of cancer-related deaths in the United States, and cases are increasing—especially among younger adults. Because our genes haven’t changed significantly over the past few generations, researchers believe environmental factors such as diet, pollution, chemicals, and chronic inflammation may play an important role.

The Project:

This study will use a new, highly advanced blood test to look for tiny chemical “fingerprints” left behind by these environmental exposures. By identifying these fingerprints, researchers hope to better understand what increases a person’s risk of developing colorectal cancer and how the disease progresses.

The research has three main goals:

  • Confirm previous findings using a more sensitive testing method.
  • Discover new blood markers that may help identify people at higher risk for colorectal cancer.
  • Better understand how environmental exposures contribute to the development and progression of the disease.

The Impact:

Ultimately, this work could lead to earlier detection, more personalized screening, and new ways to prevent colorectal cancer before it develops. By identifying risk factors that people may be able to change, this research has the potential to improve outcomes and reduce the impact of colorectal cancer for future generations.